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The Euclidean mixed isoperimetric-isodiametric inequality states that the round ball maximizes the volume under constraint on the product between boundary area and radius. The goal of the paper is to investigate such mixed isoperimetric-isodiametric inequalities in Riemannian manifolds. We first prove that the same inequality, with the sharp Euclidean constants, holds on Cartan-Hadamard spaces as well as on minimal submanifolds of