Modelling human cancer cell lines exposed to a range of cancer therapies

Tumour cells taken from human patient tissues and grown in the laboratory (in vitro) over many years are termed human tumour cell lines. These cell lines are the first port of call when investigating different cancer therapies (i.e chemotherapy and radiation). In general most therapies are described in terms of their effects within the cell cycle. Often they induce cell cycle arrest and subsequent cell death. Any general mathematical model must incorporate all these features and should be able to output experimental data.

In this presentation I will discuss the development and results of a general model of a cell line both unperturbed and perturbed by a number of cancer therapies.