A Poisson model for gapped local alignments

  • Dirk Metzler (Department of Mathematics, University of Frankfurt)
Großer Saal Alte Handelsbörse Leipzig (Leipzig)


High score alignments of DNA sequences give evidence of a common ancestry or function. It is therefore natural to ask whether an observed high score could have arisen by pure chance, and to explore what the high score alignments look like under the null hypothesis of unrelated sequences. We introduce and investigate a simple Poisson model which reflects important features of high score gapped local alignments of independent sequences.

9/17/01 9/20/01

Genes, Cells, Populations - Mathematics and Biology

Alte Handelsbörse Leipzig Großer Saal

A. Greven

A. v.Haeseler

Angela Stevens

A. Wakolbinger