Network perspective on a biologically-relevant chemical space

Human well-being is affected by exposure to chemicals in environment. Endocrine disrupting chemicals (EDCs) are one such group of emerging concern that have the ability to perturb the normal functioning of human beings. In order to screen EDCs in our daily life, we have developed a detailed workflow which was employed to process ~16000 scientific abstracts to identify more than 650 EDCs with supporting experimental evidence. In this talk, I will present results from the network-based exploration of the chemical space of EDCs which will highlight the challenges in separating EDCs from safe chemicals in our environment.

Ref: B.S. Karthikeyan et al, Science of the Total Environment 692, 281-296 (2019).