Robustness and the Evolution of Development
- David Krakauer (Santa Fe Institute, Santa Fe, USA)
During development complex phenotypes are formed without immediate natural selective feedback. I will discuss the crucial role of hierarchy - both in gene expression, signaling and in cell architecture - in promoting local selective processes that stabilize developmental patterning. I will review some of the data on gene knockouts and relate these empirical results to the idea of facilitated variation.