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conference
04.10.10 06.10.10

Multi-scale dynamics and evolvability of biological networks

Scientific Objectives

A major challenge in systems biology is to understand the dynamics of biological networks at different scales of organization, and to integrate this knowledge into models, thereby exhibiting functional sub-networks embedded in larger dynamical systems. Multi-scale dynamics is at the heart of biological function: proteins and RNA molecules, for example, may be seen as elementary computational devices that capture various types of information from the cellular environment, providing the bottom layer of cellular dynamics from which emerge the functional networks of metabolism, signal transduction and gene regulation. Similarly, the genome not only codes for proteins, but it also determines the dynamical processing of this information in space and time via gene regulatory networks and in the epigenetic organization of the genome. The multi-scale architecture of biological networks has been shaped by evolution, and it clearly strongly influences the evolvability of organisms, i.e. their potential to adopt new functions or new phenotypes. Thus evolutionary frameworks are also necessary for us to reach a good understanding of the how and why of cellular dynamics.

The main objective of this interdisciplinary workshop is to bring together leading scientists in key fields for integrated modeling of the function and evolution of biological networks, namely: gene regulatory networks, epigenomics, metabolic networks, RNA, and evolution of biological networks. While the main focus will be on the theoretical (modeling) side, recent advances from experiments will also be considered to identify important problems that challenge existing modeling paradigms. As a major outcome, we expect the identification of common questions and promising lines of research at the interfaces of functional sub-networks, possibly leading to a future integration into more detailed and more realistic models of biological systems.

The workshop is supported by the Max Planck Society (MPG) and the Centre national de la recherche scientifique (CNRS), through the CNRS-MPG joint program in systems biology.

Speakers

Fatihcan Atay

Max Planck Institute for Mathematics in the Sciences (Leipzig), Germany Homepage

Erich Bornberg-Bauer

University of Münster, Germany Homepage

Stefan Bornholdt

University of Bremen, Germany Homepage

Christine Dillmann

Université Paris-Sud (Gif sur Yvette), France Homepage

Peter Dittrich

FSU Jena, Germany Homepage

Barbara Drossel

Technical University of Darmstadt, Germany Homepage

Silvio Franz

Université Paris-Sud (Orsay), France Homepage

Jörg Galle

University of Leipzig, Germany Homepage

Thilo Gross

Max Planck Institute for the Physics of Complex Systems (Dresden), Germany Homepage

Vincent Hakim

École normale supérieure (Paris), France Homepage

Hervé Isambert

Institut Curie (Paris), France Homepage

Ivan Junier

ISC PIF (Paris), France Homepage

Steffen Klamt

Max Planck Institute for Dynamics of Complex Technical Systems (Magdeburg), Germany Homepage

Juan F. Poyatos

Spanish National Biotechnology Centre CNB (Madrid), Spain Homepage

Sonja J. Prohaska

University of Leipzig, Germany Homepage

Olivier Rivoire

Université Joseph Fourier (Grenoble), France and CNRS (Grenoble), France Homepage

Peter Stadler

University of Leipzig, Germany Homepage

Sarah Teichmann

University of Cambridge, United Kingdom Homepage

Program

08:30 - 08:40
08:35 - 08:40
08:40 - 09:15 Fatihcan Atay (Max Planck Institute for Mathematics in the Sciences, Leipzig, Germany)
09:15 - 09:50 Thilo Gross (Max Planck Institute for the Physics of Complex Systems, Dresden, Germany)
09:50 - 10:25 Peter Dittrich (FSU Jena, Jena, Germany)
10:25 - 10:55
10:50 - 10:55
10:55 - 11:30 Hervé Isambert (Institut Curie, Paris, France)
11:30 - 12:05 Peter Stadler (University of Leipzig, Leipzig, Germany)
12:05 - 14:00
13:55 - 14:00
14:00 - 14:35 Sonja J. Prohaska (University of Leipzig, Leipzig, Germany)
14:35 - 15:10 Ivan Junier (ISC PIF, Paris, France)
15:10 - 15:20
15:15 - 15:20
15:20 - 15:55 Steffen Klamt (Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany)
15:55 - 16:30 Christine Dillmann (Université Paris-Sud, Gif sur Yvette, France)
16:30 - 17:15
17:15 - 18:15
19:00 - 20:00
20:00 - 21:00
08:25 - 08:30
08:30 - 09:05 Jörg Galle (University of Leipzig, Leipzig, Germany)
09:05 - 09:40 Erich Bornberg-Bauer (University of Münster, Münster, Germany)
09:40 - 10:15 Olivier Rivoire (Université Joseph Fourier, Grenoble, France)
10:15 - 10:45
10:40 - 10:45
10:45 - 11:20 Silvio Franz (Université Paris-Sud, Orsay, France)
11:20 - 11:55 Barbara Drossel (Technical University of Darmstadt, Darmstadt, Germany)
11:55 - 13:55
13:40 - 13:45
13:45 - 14:20 Juan F. Poyatos (Spanish National Biotechnology Centre CNB, Madrid, Spain)
14:20 - 14:55 Sarah Teichmann (University of Cambridge, Cambridge, United Kingdom)
14:55 - 15:20
15:15 - 15:20
15:20 - 15:55 Vincent Hakim (École normale supérieure, Paris, France)
15:55 - 16:30 Stefan Bornholdt (University of Bremen, Bremen, Germany)
16:30 - 17:30

Participants

Christian Arnold

University of Leipzig, Germany

Fatihcan Atay

Max Planck Institute for Mathematics in the Sciences, Germany

Georg Basler

Max Planck Institute for Molecular Plant Physiology, Germany

Ingo Bathmann

University of Bremen, Germany

Ulrich Behn

University of Leipzig, Germany

Philipp Benner

Max Planck Institute for Mathematics in the Sciences, Germany

Erich Bornberg-Bauer

University of Münster, Germany

Stefan Bornholdt

University of Bremen, Germany

Pierre-Yves Bourguignon

Max Planck Institute for Mathematics in the Sciences, Germany

Sylvain Chevallier

Université Paris-Sud / INRIA, France

Edward Clark

University of York, United Kingdom

Christine Dillmann

Université Paris-Sud, France

Peter Dittrich

FSU Jena, Germany

Barbara Drossel

Technical University of Darmstadt, Germany

Andrée Ehresmann

Université de Picardie Jules Verne, Amiens, France

Gabi Escuela

Friedrich-Schiller-Universität Jena, Germany

Eric Fanchon

CNRS, France

Illes J Farkas

Hungarian Academy of Sciences, Hungary

Juan Daniel Florez Weidinger

Max Planck Institute for Dynamics and Selforganization, Germany

Silvio Franz

Université Paris-Sud, France

Jörg Galle

University of Leipzig, Germany

Eva Gehrmann

Technical University of Darmstadt, Germany

Fakhteh Ghanbarnejad

Leipzig University, Germany

Varun Giri

University of Delhi, India

Ivo Große

Martin-Luther-Universität Halle-Wittenberg, Germany

Thilo Gross

Max Planck Institute for the Physics of Complex Systems, Germany

Jiao Gu

Max Planck Institute for Mathematics in the Sciences, Germany

Vincent Hakim

École normale supérieure, France

Martin Heusel

Johannes Kepler Universität Linz, Austria

Hervé Isambert

Institut Curie, France

Jürgen Jost

Max Planck Institute for Mathematics in the Sciences, Germany

Ivan Junier

ISC PIF, France

François Képès

CNRS and Genopole®, France

Steffen Klamt

Max Planck Institute for Dynamics of Complex Technical Systems, Germany

Yasuaki Kobayashi

Fritz Haber Institute, Germany

Peter Kreyssig

FSU Jena, Germany

Axel Krinner

University of Leipzig, Germany

Andreas Kuehn

Universitaet Leipzig, Germany

Olivier C. Martin

Université Paris-Sud, France

Katja Nowick

MPI fuer Molecular Genetics, Germany

Priya Pathak

Leipzig university, Germany

Juan F. Poyatos

Spanish National Biotechnology Centre CNB, Spain

Sonja J. Prohaska

University of Leipzig, Germany

Stephan Richter

Friedrich-Schiller-Universität Jena, Germany

Olivier Rivoire

Université Joseph Fourier, France

Thimo Rohlf

Epigenomics Project, CNRS/Genopole, France

Areejit Samal

Université Paris-Sud, France

Marc Santolini

Ecole Normale Superieure, France

Camilo Sarmiento

MPI-MIS, Germany

Klaus Scherrer

Institut Jacques Monod, France

Holger Schmidtchen

Universität Leipzig / MPI MIS Leipzig, Germany

Heinz Seder

University of Leipzig, Germany

Plamen Simeonov

JSRC, Germany

Param Priya Singh

Institut Curie, France

Peter Stadler

University of Leipzig, Germany

Richard Stein

Institut Curie, France

Lydia Steiner

University of Leipzig, Germany

Korbinian Strimmer

Universität Leipzig, Germany

Sarah Teichmann

University of Cambridge, United Kingdom

Alexander Ullrich

University of Leipzig, Germany

Li Wei

MIS, Germany

Sven Willner

Uni Leipzig, Germany

Gabriel Wittum

University of Frankfurt, Germany

Carsten Wiuf

Aarhus University, Denmark

Claire Wolfrom

Université Paris-Sud, France

Marcin Zagórski

Jagiellonian University, Institute of Physics, Poland

Scientific Organizers

Thimo Rohlf

Max-Planck-Institut für Mathematik in den Naturwissenschaften and Genopole®, CNRS , Évry, France

Areejit Samal

Max-Planck-Institut für Mathematik in den Naturwissenschaften and Laboratoire de Physique Théorique et Modèles Statistiques (LPTMS) Univ. Paris-sud, France

Administrative Contact

Antje Vandenberg

Max-Planck-Institut für Mathematik in den Naturwissenschaften Contact via Mail