An introduction to the mathematical structure of the Wright–Fisher model of population genetics
Tat Dat Tran, Julian Hofrichter,and Jürgen Jost
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Submission date: 21. Mar. 2014
published in: Theory in biosciences, 132 (2013) 2, p. 73-82
DOI number (of the published article): 10.1007/s12064-012-0170-3
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In this paper, we develop the mathematical structure of the Wright–Fisher model for evolution of the relative frequencies of two alleles at a diploid locus under random genetic drift in a population of fixed size in its simplest form, that is, without mutation or selection. We establish a new concept of a global solution for the diffusion approximation (Fokker–Planck equation), prove its existence and uniqueness and then show how one can easily derive all the essential properties of this random genetic drift process from our solution. Thus, our solution turns out to be superior to the local solution constructed by Kimura.